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Evaluation of Ultrasound and PET/CT in the Diagnosis and Monitoring of Giant Cell Arteritis

NCT03765424 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 101

Last updated 2021-10-04

No results posted yet for this study

Summary

The aim of this project is to prospectively evaluate the diagnostic accuracy of different imaging tools in specific giant cell arteritis disease subsets before and after treatment initiation. Diagnostic tools with high sensitivity and specificity are a prerequisite for optimal treatment of GCA patients.

Specifically, the diagnostic accuracy of ultrasound (US) as compared to 18F-FDG PET/CT in new-onset, treatment naïve large vessel(LV)-GCA patients is investigated. Furthermore, long-term follow up including US, 18F-FDG PET/CT and cross sectional imaging is performed to explore the potential of imaging as monitoring and prognostic tools.

In this observational cohort, the diagnostic accuracy of 18F-FDG PET/CT after three and ten days of glucocorticoid treatment in the subset of LV-GCA patients and the diagnostic accuracy of 18F-FDG PET/CT in cranial artery inflammation in new-onset, treatment naïve c-GCA patients as compared to a control group of patients with a previous diagnosis of malignant melanoma was also evaluated and is registered elsewhere (ClinicalTrials.gov Identifier: NCT03285945 and NCT03409913, respectively)

Conditions

  • Giant Cell Arteritis
  • Vasculitis

Interventions

DIAGNOSTIC_TEST

Ultrasound

Ultraosund of temporal, carotid and axillary arteries

Sponsors & Collaborators

  • The Danish Rheumatism Association

    collaborator OTHER

  • Hartmann Fonden

    collaborator OTHER

  • AP Moeller Foundation

    collaborator OTHER

  • Aase and Ejnar Danielsens Foundation

    collaborator OTHER

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Berit Nielsen, MD · Department of Rheumatology

Eligibility

Min Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2014-10-01
Primary Completion
2018-07-01
Completion
2018-12-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03765424 on ClinicalTrials.gov