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Effect of Cryotherapy on Postoperative Pain for Pulpotomy

NCT07245004 · Status: ACTIVE_NOT_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 82

Last updated 2026-02-02

No results posted yet for this study

Summary

The goal of this clinical trial is to investigate the effect of cryotherapy on post-operative pain for pulpotomny in permanent mature carious posterior teeth with symptomatic irreversible pulpitis. The main question is: Do cryotherapy reduce post-operative pain and improve QoL in interested samples?

\[primary hypothesis or outcome measure 1\] Post-operative pain by Numerical rating scale scores.

\[primary hypothesis or outcome measure 2\] QoL of patients by OHIP-14

If there is a comparison group: Researchers will compare pulpotomy incorperated with cryotherapy and without.

Participants will scoring VAS scores and OHIP-14 before and after treatment at designated time points.

Conditions

  • Pulpitis - Irreversible

Interventions

OTHER

Cryotherapy

After hemostasis is achieved, the pulpotomy area is irrigated for 5 minutes with normal saline solution, which is kept in the refrigerator set to 2.5°C (measuring with thermometer and record) by using a disposable insulated 5 ml syringe and 21-gauge needle is placed 1-2 mm above the root canal orifices and is constantly moved in a circular motion: 5 ml in each of 4 syringes, administered every 1.25 minutes per syringe.

Sponsors & Collaborators

  • Chulalongkorn University

    collaborator OTHER

  • Sirawut Hiran-us

    lead OTHER

Principal Investigators

  • Sirawut Hiran-us, DDS, MSc, High Grad Dip, FRCDS · Faculty of Dentistry, Chulalongkorn University

  • Sawat Pojlerdarun, DDS, Higher Grad Dip, FRCDS · Dental Department, Yala Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-01-21
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Thailand

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07245004 on ClinicalTrials.gov