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The Effect of Cryotherapy on the Outcome of Pulpotomy and Root Canal Treatment

NCT06183021 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 144

Last updated 2026-04-06

No results posted yet for this study

Summary

The goal of this randomized clinical trial is to compare the outcome of total amputation and root canal treatment with or without cryotherapy in terms of postoperative pain, quality of life, and treatment success for the management of deep dentinal caries. The main questions it aims to answer are:

Does cryotherapy influence the outcome, life quality and treatment success in total pulpotomy? Does cryotherapy influence the outcome, life quality and treatment success in root canal treatment? Does the outcome of total pulpotomy and root canal treatment differ in cases of pulpitis?

There are 4 experimental groups:

1. Total pulpotomy with cryotherapy group
2. Total pulpotomy group (Control 1)
3. Root canal treatment with cryotherapy group
4. Root canal treatment group (Control 2)

Conditions

  • Pulpitis
  • Caries; Dentin
  • Pain, Postoperative

Interventions

PROCEDURE

Vital pulp cryotherapy

Shaved ice made from sterile distilled water will be applied around the treated tooth especially in contact with amputated pulp tissue until totally dissolves.

PROCEDURE

Intracanal cryotherapy

After mechanical preparation, a 5-minute final irrigation with 20 mL cold saline (2.5 Centigrade degrees) will be applied using a negative pressure irrigation technique per canal.

Sponsors & Collaborators

  • Ondokuz Mayıs University

    lead OTHER

Principal Investigators

  • Cangül Keskin, PhD · Ondokuz Mayıs University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-13
Primary Completion
2025-01-01
Completion
2026-03-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06183021 on ClinicalTrials.gov