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Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery

NCT07231731 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 48

Last updated 2025-11-19

No results posted yet for this study

Summary

Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences. The goal of this observational study was to investigate the mechanisms of cognitive decline after cardiac surgery and potential biomarkers that could aid in the diagnosis, prevention, and treatment of POCD. The investigators focused on the role of microRNAs (miRNAs) and systemic inflammatory response to surgery, extracorporeal circulation, and anesthesia as potential factors involved in the development of the neuroinflammatory response and subsequent POCD. The main question this study aims to answer is whether perioperative miRNA 151-5p expression is associated with POCD after surgery. The second aim is to examine the association between miRNA-151-5p and systemic inflammation. The investigators measured circulating miRNA-151-5p levels and plasma levels of inflammatory biomarkers in patients undergoing surgical myocardial revascularization. To assess cognitive function, participants completed the Montreal Cognitive Assessment (MoCA Test). Changes in the measured values of miRNA-151-5p expression and inflammatory markers, as well as changes in cognitive status after surgery, were assessed in relation to the preoperative state.

Conditions

  • Biomarkers
  • Coronary Artery Bypass Surgery
  • Interleukin-6
  • MicroRNAs
  • Postoperative Cognitive Complications
  • Systemic Inflammatory Response Syndrome

Sponsors & Collaborators

  • Josip Juraj Strossmayer University of Osijek

    collaborator OTHER

  • Osijek University Hospital

    lead OTHER

Principal Investigators

  • Slavica Kvolik, Professor · University Hospital Osijek

Eligibility

Min Age
65 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-05-31
Primary Completion
2023-06-23
Completion
2023-10-26

Countries

  • Croatia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07231731 on ClinicalTrials.gov