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Impact of Exogenous Ketones on Breathing in Healthy Volunteers

NCT07220122 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-03-31

No results posted yet for this study

Summary

Exogenous ketones (EK) are compounds that can increase the level of ketones in the body without needing to change what an individual eats.

Although EK have been researched mainly in relation to energy and exercise, there haven't been many studies focusing specifically on how EKs affect breathing using well-established scientific methods. The investigators believe that EK may help improve breathing, which could be beneficial for situations like high altitudes, sleep apnea, and exercise.

To explore how EK might influence breathing, the investigators are conducting a randomized, placebo-controlled crossover study with healthy volunteers.

Conditions

  • Healthy Volunteer

Interventions

DIETARY_SUPPLEMENT

1,3 butanediol

40 mg Ketone-IQ beverage

DIETARY_SUPPLEMENT

Placebo

Placebo (taste matched)

Sponsors & Collaborators

Principal Investigators

  • Jonathan C Jun, MD · Johns Hopkins University

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-12
Primary Completion
2027-01-10
Completion
2027-02-10

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07220122 on ClinicalTrials.gov