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The Effects of Ketone Supplements With Carbohydrates on Cycling Performance Above Lactate Threshold

NCT07224282 · Status: NOT_YET_RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2025-11-04

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether a ketone supplement with carbohydrates extends time to fatigue during cycling compared with a carbohydrate-only supplement in healthy, trained cyclists aged 18-55. The main questions it aims to answer are:

Is the time to fatigue increased with ketone supplementation and carbohydrates compared to carbohydrates alone? Will ketone supplementation with carbohydrates produce lower blood lactate concentrations compared to carbohydrates alone?

Participants will:

* Perform a staged maximal cycling exercise test on a stationary bicycle.
* Finger prick to obtain a drop of blood for lactate measurements.
* Wear a mask connected to a metabolic cart to measure breath contents.
* Perform a cycling exercise test to fatigue for at least one hour.
* Consume either a ketone supplement with carbohydrates or a carbohydrate supplement during the exercise at least 4 times.
* Finger prick to obtain a drop of blood to measure blood lactate, ketones, and glucose.

Conditions

  • Exogenous Ketosis

Interventions

DIETARY_SUPPLEMENT

Ketone supplementation

30-gram carbohydrate beverage with 5 grams of R-1,3-Butanediol every 30 minutes of experimental visit

DIETARY_SUPPLEMENT

Carbohydrate

30-gram carbohydrate beverage with bitter flavoring

Sponsors & Collaborators

  • University of Oklahoma

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-11-17
Primary Completion
2026-03-09
Completion
2026-05-03
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07224282 on ClinicalTrials.gov