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FAXAGE: Fasting And Exercise To Slow Aging In Humans

NCT07207044 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2026-01-28

No results posted yet for this study

Summary

FAXAge is a randomized controlled trial investigating the effects of fasting and exercise on human aging. 240 participants over the age of 65 will be divided into 4 groups - an exercise group, a fasting group, a combined exercise and fasting group and a control group. The intervention will last for one year, and tests of biomarkers of aging will be performed at baseline, after 3 months, 6 months and at the end of the intervention. A reference group of participants over the age of 20 equally distributed by age and sex will be used to train an algorithm for determination of biological age. The study will include both physical, molecular and digital biomarkers including DNA-methylation, VO2max, body composition and face- and voice-age. The main outcome of the project is DNA-methylation age at week 52. Secondary outcomes are the rest of the tested biomarkers at week 52. It is hypothesised that the intervention groups will have similar superior benefits after the 52 weeks of intervention.

Conditions

  • Aging
  • Healthy Aging
  • Aging Frailty

Interventions

BEHAVIORAL

Exercise - Strength + Cardio

Supervised strength training 2x/week + self-administered cardio training 2x/week.

BEHAVIORAL

Time-restricted feeding

Time-restricted feeding in a 16/8 regimen - 16 hours of fast and 8 hours of eating per day.

BEHAVIORAL

Time-restricted feeding + Exercise

Strength and cardio exercise 2x/week each combined with time-restricted feeding in a 16/8 regimen.

Sponsors & Collaborators

  • University of Copenhagen

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-01
Primary Completion
2027-08-30
Completion
2042-08-30

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07207044 on ClinicalTrials.gov