Oral Carnitine in Heart Failure Patients
NCT07201714 · Status: RECRUITING · Phase: EARLY_PHASE1 · Type: INTERVENTIONAL · Enrollment: 20
Last updated 2026-04-20
Summary
Heart failure is a condition in which the heart is unable to pump blood effectively, leading to symptoms like being more tired, shortness of breath, and swelling in the body. Carnitine is a naturally occurring substance in the body that plays a role in turning fat into energy. This study will determine whether oral L-Carnitine supplementation can improve symptoms, enhance heart function and possibly improve the quality of life in individuals with heart failure.
Conditions
- Heart Failure
- Carnitine Deficiency
Interventions
- DRUG
-
Levocarnitine
Oral L-carnitine, 2970mg daily (950mg, to be taken 3 times a day) for 3 months.
Sponsors & Collaborators
-
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
lead OTHER
Principal Investigators
-
Chris McIntyre, MBBS DM · London Health Sciences Centre
Study Design
- Allocation
- NA
- Purpose
- HEALTH_SERVICES_RESEARCH
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-11-12
- Primary Completion
- 2026-12-31
- Completion
- 2026-12-31
Countries
- Canada
Study Locations
More Related Trials
-
Efficacy and Safety of Human Neuregulin-1 to Treat Stable Chronic Heart Failure
NCT01251406 ·Status: COMPLETED ·Phase: PHASE2
-
Physiological Effects Ketone Ester in Heart
NCT05924802 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Study to Evaluate the Effects of Oral Administration of Lixivaptan in Patients With Congestive Heart Failure
NCT01055912 ·Status: COMPLETED ·Phase: PHASE2
-
Thiamine Supplementation to Improve Cardiac Function in Patients With Congestive Heart Failure
NCT00770107 ·Status: COMPLETED ·Phase: NA
-
The Effect of Nicotinamide Riboside on Skeletal Muscle Function in Heart Failure Subjects
NCT03565328 ·Status: TERMINATED ·Phase: PHASE2
-
Impact of Darbepoetin Alfa on Exercise Tolerance and Left Ventricular Structure in Subjects With Symptomatic Congestive Heart Failure (CHF) and Anemia
NCT00117234 ·Status: COMPLETED ·Phase: NA
-
Thiamine Supplementation in Heart Failure Patients Receiving Full Medical Therapy
NCT01115504 ·Status: COMPLETED ·Phase: PHASE3
-
Effects of Dietary Nitrate Supplementation on Cardiorespiratory Control in Chronic Heart Failure
NCT02401126 ·Status: COMPLETED ·Phase: PHASE4
-
Effect of Rapamycin to Improve Cardiac Function in Frail Older Adults
NCT04996719 ·Status: COMPLETED ·Phase: PHASE1
-
Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial
NCT03228030 ·Status: COMPLETED ·Phase: PHASE1
-
Modulation of Circulating Levels of the Ketone Body 3-hydroxybutyrate in Patients With Chronic Heart Failure: Cardiovascular Effects
NCT04443426 ·Status: UNKNOWN ·Phase: PHASE2
-
Dietary Supplementation in Heart Failure
NCT03980574 ·Status: COMPLETED ·Phase: NA
-
A Trial of Thiamin Supplementation in Patients With Heart Failure
NCT00959075 ·Status: COMPLETED ·Phase: PHASE4
-
Nicotinamide Riboside in Systolic Heart Failure
NCT03423342 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Ketones in Heart Failure - Effects on Cardiac Efficiency
NCT03073356 ·Status: COMPLETED ·Phase: PHASE2
-
Effectiveness of Oral Anticoagulants in Elderly Patients With Non-Valvular Atrial Fibrillation and Heart Failure
NCT03508271 ·Status: COMPLETED
-
CoQ10 and D-ribose in Patients With Diastolic Heart Failure
NCT03133793 ·Status: COMPLETED ·Phase: PHASE2
-
Mechanistic Studies of Nicotinamide Riboside in Human Heart Failure
NCT04528004 ·Status: ACTIVE_NOT_RECRUITING ·Phase: EARLY_PHASE1
-
Nutritional Ketosis in Heart Failure
NCT04370600 ·Status: UNKNOWN ·Phase: PHASE1
-
A Phase I/II Clinical Study of SK&F-105517-D in Japanese Patients With Chronic Heart Failure
NCT00742508 ·Status: COMPLETED ·Phase: PHASE1
-
Evaluate the Effect of Injectable Neucardin on the Cardiac Function of Subjects With Chronic Systolic Heart Failure
NCT04468529 ·Status: COMPLETED ·Phase: PHASE3
-
Ketones in Heart Failure With Reduced Ejection Fraction
NCT06195982 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE2
-
A Research Study on the Effects of NNC0537-1482 in Healthy Individuals When Injected Under the Skin
NCT06625307 ·Status: COMPLETED ·Phase: PHASE1
-
Acute and Chronic Effects of Oral Ketones in Subjects With HFrEF and Diabetes
NCT06108076 ·Status: RECRUITING ·Phase: EARLY_PHASE1
-
The Effect of Ribose on B-Type Natriuretic Peptide (BNP) Levels in Congestive Heart Failure Patients
NCT00329485 ·Status: TERMINATED ·Phase: NA