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Ketones in Heart Failure - Effects on Cardiac Efficiency

NCT03073356 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2017-12-11

No results posted yet for this study

Summary

Ketones may have beneficial effects on myocardial metabolism and hemodynamics. In the present study, healthy test subjects and patients with heart failure with reduced ejections fraction will be investigated in a randomized cross-over design with ketone infusions and placebo. Myocardial efficiency and hemodynamics will be evaluated.

Conditions

  • Heart Failure, Systolic
  • Ketonemia

Interventions

BIOLOGICAL

Infusion of 3-OHB

Increase in 3-OHB levels

BIOLOGICAL

Infusion of placebo

NaCl

Sponsors & Collaborators

  • University of Aarhus

    lead OTHER

Principal Investigators

  • Roni R Nielsen, MD PHD · Dept. of Cardiology

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-03-17
Primary Completion
2017-11-16
Completion
2017-11-16

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03073356 on ClinicalTrials.gov