MedTrace Logo

Thiamine Supplementation in Heart Failure: a Pilot Randomized Controlled Crossover Trial

NCT03228030 · Status: COMPLETED · Phase: PHASE1 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2021-08-31

No results posted yet for this study

Summary

Heart failure (HF) is a major cardiovascular disease with increasing prevalence. Thiamine deficiency is common in HF patients. Previous small studies have shown that thiamine supplementation can improve left ventricular systolic function in HF, but larger clinical studies are lacking. Given the ease of supplementation and the potential benefits in HF, we aim to conduct a pilot randomized controlled trial (RCT) using high dose thiamine supplementation in HF patients. The main goal of this pilot study is to determine the feasibility of recruitment for an RCT of thiamine supplementation.

Conditions

  • Heart Failure
  • Heart Failure With Reduced Ejection Fraction
  • Thiamine Deficiency
  • Congestive Heart Failure

Interventions

DIETARY_SUPPLEMENT

Thiamine

Capsules

DIETARY_SUPPLEMENT

Placebo

Identical capsules

Sponsors & Collaborators

  • McMaster/St. Peter's Hospital Chair of Aging

    collaborator UNKNOWN

  • Hamilton Health Sciences Corporation

    lead OTHER

Principal Investigators

  • Eric KC Wong, MD FRCPC · McMaster University

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
CROSSOVER

Eligibility

Min Age
60 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-04-02
Primary Completion
2021-04-30
Completion
2021-04-30

Countries

  • Canada

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03228030 on ClinicalTrials.gov