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Exercise, IMA and Sulfhydryl Biomarkers in Young Women

NCT07181044 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 30

Last updated 2025-09-23

No results posted yet for this study

Summary

Background: Regular physical activity exerts systemic health benefits that extend to redox homeostasis and antioxidant defense mechanisms. Ischemia-modified albumin (IMA) and total sulfhydryl groups (-SH) are increasingly recognized as sensitive biomarkers reflecting oxidative protein modification and thiol-dependent antioxidant capacity, respectively. However, data on their interplay in young women engaged in structured exercise remain scarce.

Objective: This study aimed to investigate the effects of regular exercise on serum IMA and -SH concentrations in healthy young women, thereby providing insights into exercise-induced redox remodeling and sex-specific physiological adaptations.

Methods: A cross-sectional design was employed involving 30 healthy women aged 18-25 years. Participants were divided into an exercise group (n = 15), who had performed structured training ≥3 sessions per week for at least one year, and a control group (n = 15) with no structured exercise history. Venous blood samples were collected after overnight fasting. Serum IMA was quantified using the albumin-cobalt binding assay, and -SH concentrations were determined via the Ellman method. All analyses were performed in duplicate under standardized laboratory conditions. Independent samples t-tests were applied, and effect sizes (Cohen's d) were calculated with 95% confidence intervals.

Conditions

  • Healthy Young Women
  • Regular Exercise
  • Oxidative Stress
  • Redox Homeostasis
  • Antioxidant Defense
  • Biomarkers
  • Sports Physiology

Sponsors & Collaborators

  • Duvenciler Anadolu Lİsesi

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
25 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-01-20
Primary Completion
2022-02-20
Completion
2022-03-20

Countries

  • Turkey (Türkiye)

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07181044 on ClinicalTrials.gov