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The Role of Decortication in Complex Empyema Cases: Multidrug Resistance and Tuberculosis at the Forefront

NCT07167823 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 350

Last updated 2025-09-15

No results posted yet for this study

Summary

Empyema is a problem that thoracic surgeons deal in everyday practice. The main goal of treatment is evacuating the pus and fibrin deposits in the thoracic cavity for complete lung expansion. This study aims to report a detailed microbiological profile of patients operated for empyema thoracis and also correlate it with perioperative clinical outcomes. Patients who underwent surgery for empyema thoracis between January 2022 to June 2025 were included in the study. This study was carried out at two centers; Thoracic Surgery Department, Services Hospital Lahore. Patients were taken up for surgery after thorough preoperative evaluation. Perioperative outcomes were correlated with the results of microbiological analysis to evaluate their effect on clinical outcomes. This study highlights the emergence of Gram-negative organisms in bacterial empyema and emergence of multidrug resistance in tubercular empyema. Clinical outcome correlation revealed increased complications in culture-positive cases in both tubercular and nontubercular empyemas

Conditions

  • Pleural Empyema
  • Tuberculosis (TB)
  • Bacterial Sepsis

Interventions

PROCEDURE

Decortication

removal of fibrinous infected material from pleural cavity and thick fibrous entrapping peel over the lung resulting in full expansion of lung.

PROCEDURE

Decortication

removal of fibrinous infected material and thick fibrinous entrapping peel over the lung

Sponsors & Collaborators

  • University of Health Sciences Lahore

    lead OTHER

Principal Investigators

  • Muhammad Shoaib Nabi, Professor of Thoracic Surgery · Services Hospital, Lahore

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2022-01-01
Primary Completion
2025-06-30
Completion
2025-08-31

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07167823 on ClinicalTrials.gov