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Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches

NCT07165808 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 84

Last updated 2026-02-27

No results posted yet for this study

Summary

The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.

Primary objective is to assess the effect of variation in nicotine concentration in nicotine pouches (NPs) and its interaction effect with pH level on three proximal outcomes of relevance to regulation: (1) sensory experience, (2) product appeal, and (3) abuse liability of NPs.

Conditions

  • Nicotine Addiction

Interventions

OTHER

Nicotine pouch: Low dose

Nicotine pouch: 3-4 mg

OTHER

Nicotine pouch: High dose

Nicotine pouch: 6-8 mg

OTHER

Low pH

Nicotine pouch with low pH level \[\<8.5\]

OTHER

High pH

Nicotine pouch with high pH level \[\>8.5\]

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • Emory University

    lead OTHER

Principal Investigators

  • Dae Han, PhD · Rollins School of Public Health

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
21 Years
Max Age
35 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-02-13
Primary Completion
2028-01-31
Completion
2028-01-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07165808 on ClinicalTrials.gov