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Comparison of Demand and Substitution for Nicotine Pouches as a Function of Nicotine Dosage

NCT07213947 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 1360

Last updated 2026-05-01

No results posted yet for this study

Summary

Smoking is a prominent public health issue. Traditional nicotine replacement therapy suffers from being a poor substitute for cigarettes. Novel tobacco products, such as nicotine pouches, show promise as potential low-harm substitutes. Investigators wish to assess the substitutability of cigarettes for nicotine pouches at different dosages and price points. This study will consist of 4000 screened participants online on the crowdsourcing software Prolific, with roughly 400 eligible participants. This study will include the use of an electronic tobacco marketplace.

Conditions

  • Tobacco Use
  • Nicotine Pouch Self-Administration

Interventions

OTHER

Nicotine Pouch Dosage

All participants will be experimentally manipulated by having nicotine dosage in hypothetical purchase tasks/ experimental marketplaces altered between market groups.

Sponsors & Collaborators

  • National Institute on Drug Abuse (NIDA)

    collaborator NIH

  • William Middleton

    lead OTHER

Principal Investigators

  • Mikhail Koffarnus, PhD · University of Kentucky

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-12-04
Primary Completion
2026-01-02
Completion
2026-01-02

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07213947 on ClinicalTrials.gov