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Effect of Agricultural Practices on Crops, Gut Microbiome, and Human Health

NCT07165145 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2025-09-10

No results posted yet for this study

Summary

The human gut microbiome plays a regulatory role in host health, and is involved in metabolic, immune, and neurological processes. Diet shapes the gut microbiome; by providing essential nutrients, which sustain the existing microorganisms and by introducing foodborne microbes that modulate its composition. Notably, the impact of microbes from fruit and vegetables on the gut microbiome is relatively unexplored. Differences in agricultural practices, organic vs conventional strategies, can lead to variations in nutritional content and associated microbial communities in and on crops, underscoring the potential for variations in cultivated crops to influence the human gut microbiome's composition and function. This study aims to explore how crop cultivation practices affect the composition and function of the human gut microbiome, ultimately influencing overall health.

Conditions

  • Obesity Prevention
  • Microbiome Analysis

Interventions

DIETARY_SUPPLEMENT

Organic Fruits and Vegetables

Dietary Intervention

DIETARY_SUPPLEMENT

Conventional Fruits and Vegetables

Dietary Intervention

Sponsors & Collaborators

  • Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC)

    lead OTHER

Principal Investigators

  • Max Nieuwdorp, Dr. Prof. · Dept of Vascular Medicine, Amsterdam UMC - AMC

  • Hilde H.J. Herrema, PhD · Dept of Vascular Medicine, Amsterdam UMC - AMC

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-25
Primary Completion
2026-12-20
Completion
2027-07-05

Countries

  • Netherlands

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07165145 on ClinicalTrials.gov