Cognitive and Metabolic Effects of a Probiotic Supplement

Summary

To examine the cognitive and metabolic effects of a probiotic supplement that is readily and already available for purchase in public drug stores. This study is a double-blinded randomized cross-over placebo-controlled intervention study. Participants will be randomized to receive either the probiotic supplement or the placebo during the first intervention period which will last 2 weeks. This will be followed by a washout period, after which they will proceed to the second intervention period, also lasting 2 weeks and also followed by a washout period.

Conditions

• Dietary Supplements
• Probiotics
• Metabolism
• Food Preferences
• Microbiota

Interventions

BEHAVIORAL

Inhibitory task

Participants perform a binary decision on each presented stimuli. Of the two possible outcomes, participants are instructed to make a motor response (go) for one type, and are to withhold a response (no-go) for the other type. Reaction time and accuracy are measured for each event

PROCEDURE

Blood samples

Hormone levels will be analyzed from blood samples obtained before and after a caloric preload given at each visit

BIOLOGICAL

Feces collection

Feces samples will be collected on the morning of each visit, before and after each 2-week intervention period, as well as after each 2-week washout period following each intervention period.

PROCEDURE

Caloric preload

A caloric preload will be given to participants, following which blood will be taken at 65 minutes later (specified in Blood sampling) following the ingestion of the caloric preload.

BEHAVIORAL

Food selection task

Participants are given the opportunity to write and use a computer program to specify amount and type of food would ideally like to consume

BEHAVIORAL

Memory task

Participants perform short memory tasks on each visit

BEHAVIORAL

Food consumption task

Participants are given a selection of food items to consume on each visit

Sponsors & Collaborators

• Uppsala University

  lead OTHER

Principal Investigators

• Christian Benedict, PhD · Department of Neuroscience, Uppsala University

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

DOUBLE

Model

CROSSOVER

Eligibility

Min Age

18 Years

Max Age

28 Years

Sex

MALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2013-11-30

Primary Completion

2015-12-31

Completion

2015-12-31

Countries

• Sweden

Study Locations