TIPS for Complicated Portal Hypertension Related to Porto-Sinusoidal Vascular Disease

Summary

Porto-sinusoidal Vascular Disease (PSVD) is characterized by a portal hypertension (PH) without cirrhosis. This can induce PH complications, like digestive hemorrhage from esophageal or gastric varices, ascites, or even portal thrombosis. Due to the rarity of MVPS, the treatment of complications of portal hypertension is modeled on the methods used in cirrhotic portal hypertension with non-cardio-selective beta blockers, endoscopic ligations or diuretics in first line therapy, as proposed by the Baveno VII recommendations. In complicated or refractory forms of PH in PSVD, the place of TIPS is also discussed, as in the field of cirrhosis. However, the experience of TIPS in PSVD is limited, reported in case reports and small specifically dedicated series. No predictive factors for survival or recurrence and tolerance were well known. A larger study with control group is needed in order to better know the right time and the right indication for the use of TIPS in complicated PH PSVD-related.

The study will be retrospective, multicentric involving tertiary university French centers, expert in the management of TIPS. Patients white TIPS-PSVD will be compared with historical patients with TIPS-cirrhose, matched on age, sexe, indication of TIPS. The study will not comprise new intervention, only observational in a real life condition

Conditions

• TIPS
• Portal Hypertension
• Porto-Sinusoidal Vascular Disease
• Refractory Ascite
• Esophageal Varices
• Gastrointestinal Hemorrhage

Sponsors & Collaborators

• Groupe Hospitalier Pitie-Salpetriere

  collaborator OTHER

• CHU Rennes

  collaborator UNKNOWN

• AP-HP - HU BEAUJON

  collaborator UNKNOWN

• University Hospital, Toulouse

  collaborator OTHER

• CHRU TOURS

  collaborator UNKNOWN

• Centre Hospitalier Universitaire de Besancon

  collaborator OTHER

• Hospices Civils de Lyon, France

  collaborator UNKNOWN

• APHP - HOPITAL AVICENNE

  collaborator UNKNOWN

• University Hospital, Montpellier

  collaborator OTHER

• Saint-Luc University Hospital

  collaborator UNKNOWN

• CHU Poitiers

  collaborator UNKNOWN

• CHU NICE

  collaborator UNKNOWN

• CH HENRI MONDOR

  collaborator UNKNOWN

• Saint Antoine University Hospital

  collaborator OTHER

• University Hospital, Rouen

  collaborator OTHER

• AP-HP Paul Brousse University Hospital

  collaborator UNKNOWN

• Nantes University Hospital

  collaborator OTHER

• Centre Hospitalier Universitaire Dijon

  collaborator OTHER

• University Hospital, Bordeaux

  collaborator OTHER

• University Hospital, Brest

  collaborator OTHER

• University Hospital, Clermont-Ferrand

  collaborator OTHER

• Centre Hospitalier Universitaire, Amiens

  lead OTHER

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-05-16

Primary Completion

2025-12-31

Completion

2025-12-31

Countries

• France

Study Locations