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Lactate Kinetics After Multimodal Exercise and Adjunctive Virtual Reality Exercise in Hospitalized Geriatric Patients

NCT07149272 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 153

Last updated 2026-08-17

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether adding virtual reality exercise to conventional multimodal exercise affects exercise-related lactate kinetics, functional status, frailty, sarcopenia risk, perceived exertion, and health-related quality of life in adults aged 60 years or older who are hospitalized in an acute geriatric ward.

The main questions it aims to answer are:

1. are there any difference in post exercise lactate at day 1 and 7 between the two groups?
2. does the lactate concentration reduces after low intensity resistance exercise in subject with high resting lactate?
3. Does virtual reality-assisted multimodal exercise improve functional independence, frailty status, sarcopenia risk, perceived exertion, and health-related quality of life from baseline to Day 7?

Researchers will compare participants receiving conventional multimodal exercise plus virtual reality exercise with participants receiving conventional multimodal exercise alone to evaluate the additional effects of the virtual reality intervention.

Participants will:

* Undergo functional and medical assessments before starting the exercise program.
* Receive an individualized conventional multimodal exercise program during hospitalization.
* If assigned to the intervention group, perform additional virtual reality exercise using the VRAGMENT program.
* Have capillary blood lactate concentrations measured immediately before and after standardized low-intensity resistance exercise on Day 1 and Day 7.
* Complete the following assessments at baseline and on Day 7:
* Barthel Index to assess functional independence.
* Frailty Index-40 (FI-40) to assess frailty.
* SARC-F to assess the risk of sarcopenia.
* Borg Rating of Perceived Exertion (RPE) Scale to assess perceived exercise intensity.
* EQ-5D-5L to assess health-related quality of life.
* Have vital signs, exercise tolerance, and adverse events monitored throughout the intervention.

Conditions

Interventions

DEVICE

Virtual Reality Exercise (VRE) using VRAGMENT software

Adjuvant Virtual Reality Exercise (VRE) delivered via Oculus Quest 2 headset with VRAGMENT software, a culturally adapted VR program simulating daily activities (e.g., grocery shopping, phone calls) to induce physical movement. Participants received VRE alongside conventional multimodal exercise (breathing, resistance, aerobic) during hospitalization. Sessions were tailored to individual clinical conditions and aimed to improve fatigue and mobility through gamified rehabilitation

Sponsors & Collaborators

  • Dr Cipto Mangunkusumo General Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
60 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-02-16
Primary Completion
2025-05-30
Completion
2025-05-30

Countries

  • Indonesia

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07149272 on ClinicalTrials.gov