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EVALUATION OF SALIVA AS LIQUID BIOPSY FOR EARLY DETECTION OF ORAL CANCER IN PATIENTS WITH ORAL-SUBMUCOUS FIBROSIS (OSMF)

NCT07122128 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2025-08-14

No results posted yet for this study

Summary

Oral cancer is the top cancer in Pakistan, accounting for 27%, and it has a high mortality rate due to late-stage diagnosis. It primarily affects the lips, tongue, cheeks, and floor of the mouth. Major risk factor for oral cancer development is pan supari chhaliya chewing.

Patients often develop a pre-malignant condition, oral submucous fibrosis, resulting in limited mouth opening. Thus, patients are diagnosed at an advanced level and poor survival. Therefore, saliva appears a potential mode of evaluation for early detection. This project aims to evaluate salivary cells, genes and biochemistry of the saliva among health volunteers and compare it with that of the patients with oral submucous fibrosis and oral cancer.

Conditions

  • The Study Focuses on the Saliva as Potential Source of Early Detection of Oral Cancer

Interventions

DIAGNOSTIC_TEST

saliva a a diagnostic tool for early detection of oral cancer

Three groups will be compared on the basis of cytology, genes and biochemical analysis

Sponsors & Collaborators

  • Sindh Higher Education Commission

    collaborator UNKNOWN

  • Liaquat University of Medical & Health Sciences

    lead OTHER

Principal Investigators

  • Binafsha Manzoor Prof. Syed, PhD · Liaquat University of Medical and Health Sciences

Eligibility

Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2021-06-01
Primary Completion
2025-12-30
Completion
2026-06-30

Countries

  • Pakistan

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07122128 on ClinicalTrials.gov