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Study to Evaluate the Natural History of Head and Neck Cancer Precursors in Taiwan

NCT02017288 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 3576

Last updated 2021-02-08

No results posted yet for this study

Summary

Background:

\- Cancer of the mouth and throat is one of the most common cancers in Taiwan. This cancer develops over several years, beginning as white or red patches in the mouth or throat that become growths. It can also cause a condition that leads to rigidity of the cheeks. The growths can be identified when a doctor looks into a person s mouth. It is currently not clear why some people with abnormal growths progress to cancer while others do not. Researchers want to better understand why some patients with early abnormal growths get late abnormal growths. They also want to understand why some people get abnormal growths again, even after they receive treatment.

Objectives:

\- To understand why some people with precancerous lesions in their mouth develop cancer while others do not.

Eligibility:

\- Adults 21 years and older, some with abnormal growths in the mouth, some without any, and some with head and neck cancer.

Design:

* Participants will visit a hospital in Taiwan 2 times.
* At the first visit, participants will answer questions about their health, lifestyle, and family medical history. A doctor will examine the participant s mouth and take a small piece of any growth they see. They will do this with a brush. They will also photograph the participant s mouth. Participants will also give blood and saliva samples, plus a small sample of a mouth rinse.
* Participants who are diagnosed with a late abnormal growth that is not cancer will return for a second visit. They will answer the same questions and undergo the same procedures as at the first study.

Conditions

  • Head and Neck Neoplasms

Sponsors & Collaborators

  • National Taiwan University

    collaborator OTHER

  • Academia Sinica, Taiwan

    collaborator OTHER

  • China Medical University, China

    collaborator OTHER

  • National Cancer Institute (NCI)

    lead NIH

Principal Investigators

  • Anil K Chaturvedi, M.D. · National Cancer Institute (NCI)

Eligibility

Min Age
21 Years
Max Age
100 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2013-11-18
Primary Completion
2021-02-04
Completion
2021-02-04

Countries

  • Taiwan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02017288 on ClinicalTrials.gov