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WORST PATTERN OF INVASION IN ORAL SQUAMOUS CELL CARCINOMA

NCT05927220 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 81

Last updated 2023-07-03

No results posted yet for this study

Summary

Cancer of the oral mucosa, also known as oral squamous cell carcinoma (OSCC), occurs as an ulceroproliferative lesion that can develop at any site in the mouth, from the lips to oropharynx. OSCC (Oral squamous cell carcinoma) is a biologically aggressive tumor and this has piqued interest in research into several prognostic histopathological indicators during the past few decades. The AJCC 8th edition TNM staging system incorporates histopathological factors including depth of invasion (DOI) that affect patient outcomes. Numerous studies have linked a poor prognosis and increased locoregional failure with certain \"patterns of invasion\" (POI) in OSCC. However, this factor is not utilized for treatment decision making and for outcome assessment.

The management and prognosis of oral squamous cell carcinoma (OSCC) depends on tumor stage, differentiation, perineural and lymphovascular invasion, depth of invasion, margin status, lymph node (LN) metastasis and extranodal extension. We will evaluate the relationship of these histopathological parameters with cohesive and non cohesive worst patterns of invasion (WPOI) in OSCC. The purpose of this cross-sectional study is to determine that presence of non-cohesive WPOI is associated with advanced T stage, poor differentiation, PNI, greater depth of invasion, and higher chances of nodal metastasis. WPOI is associated with poor DFS (disease free survival), treatment intensification in early stage disease with non-cohesive WPOI may improve survival.

Therefore, it should also be included in routine reporting protocol for OSCC to aid in describing the aggressive behaviour of disease.

Conditions

  • Oral Cancer
  • Oral Cavity Cancer
  • Oral Squamous Cell Carcinoma

Interventions

DIAGNOSTIC_TEST

Biopsy Specimens Histopathology

paraffin-embedded blocks with sections from the tumor will be selected. Patterns of invasion will be recorded by for all cases by histopathologists

Sponsors & Collaborators

  • Armed Forces Institute of Pathology Rawalpindi

    lead OTHER_GOV

Principal Investigators

  • Manahil Rahat, BDS · AFIP Rawalpindi Pakistan

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-07-03
Primary Completion
2023-08-31
Completion
2023-11-30

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05927220 on ClinicalTrials.gov