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Evaluate Buffering Local Anesthetic in Inflamed Teeth

NCT07120594 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2025-08-13

No results posted yet for this study

Summary

This randomized, double-blinded, split-mouth clinical trial evaluates the effect of buffering local anesthetic with sodium bicarbonate in pediatric dental extractions. Twenty children aged 6 to 10 years with two infected primary molars on opposite sides of the maxilla participated. Each child received standard anesthetic on one side and buffered anesthetic on the other. Pain levels and onset time were measured to assess anesthetic efficacy.

Conditions

  • Inflamed and Infected Primary Molars in Children
  • Effectiveness of Buffered Local Anesthesia During Dental Extraction

Interventions

DRUG

Unbuffered lidocaine 2% with epinephrine 1:80,000

Standard local anesthetic solution without pH modification. Used for maxillary extraction of infected primary molars in pediatric patients.

DRUG

Buffered lidocaine 2% with epinephrine 1:80,000

Local anesthetic solution mixed with sodium bicarbonate to increase pH before injection. Used for maxillary extraction of infected primary molars in pediatric patients.

Sponsors & Collaborators

  • Tishreen University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
6 Years
Max Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-11-08
Primary Completion
2025-07-20
Completion
2025-07-20

Countries

  • Syria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07120594 on ClinicalTrials.gov