MedTrace Logo

Multitarget Pulse Field Ablation Guided by Endocardial and Non-invasive Atrial Driver Mapping (PFA+ADM) Pilot Study. Development of an Ablation Strategy to Improve the Efficacy of Long Standing Atrial Fibrillation Ablation in Patients With High Comorbidity Burden or Heart Failure

NCT07118488 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2025-08-12

No results posted yet for this study

Summary

To assess the efficacy and safety of a percutaneous ablation strategy that targets multiple extrapulmonary structures as the Cox-Maze IV.

Conditions

  • Persistent Atrial Fibrillation Longstanding

Interventions

PROCEDURE

Multitarget PFA Ablation

* Informed consent gave by the patient. * Implantable loop recorder procedure * Clinical procedure starts * Electrophysiologycal study * Non-invasive map is obtained. * Electroanatomical map of both atria is generated. * Intracavitary electrogram (EGM) driver assessment * Pulmonary vein isolation * Extra pulmonary drivers ablation based on EGM findings (rotational and high frequency sites). * Non-invasive map is obtained to assess ablation impact on driver distribution. * Remap and extra pulmonary lesions are carried out until activity. At drivers sites disappears or decreases in at least 2 hertz or up to physician criteria. * Patient follow up

Sponsors & Collaborators

  • Fundacion para la Innovacion en Biomedicina (FIBMED)

    lead OTHER

Principal Investigators

  • Angel Arenal, MD, PhD · Hospital General Universitario Gregorio Marañón

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-31
Primary Completion
2027-07-31
Completion
2027-07-31

Countries

  • Spain

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07118488 on ClinicalTrials.gov