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The Effect of Local Melatonin Application Around Immediately Placed Implants in the Maxillary Premolar

NCT07103564 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2025-08-05

No results posted yet for this study

Summary

Background: Immediate implants provide ideal three-dimensional positioning compared to conventional implants. There may be a gap between the surface of the implant and the bone walls of the socket when it is inserted into a recently extracted alveolus. To compensate for this, various grafting materials are used. Recently, melatonin has gained significant attention because of its inhibitory action on bone resorption through upregulating the expression of osteoprotegerin, which acts as a decoy receptor for RANKL and inhibits its binding to osteoclast precursors thereby inhibiting osteoclast formation and activity. So, we will conduct this study to evaluate the effects of local melatonin application around immediately placed implants.

Aim of the study: To evaluate the effectiveness of adding local melatonin around immediately placed implants in maxillary premolars.

Conditions

  • Dental Implants
  • Osteoprotegerin
  • Melatonin

Interventions

OTHER

Immediately placed implant in maxillary premolars with local melatonin application

Patients will receive immediately placed implants with local melatonin powder (3mg) application.

OTHER

Immediately placed implant in maxillary premolars without local melatonin application

Patients will receive immediately placed implants without local melatonin application.

Sponsors & Collaborators

  • Hams Hamed Abdelrahman

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
25 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-07-01
Primary Completion
2025-07-15
Completion
2025-07-15

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07103564 on ClinicalTrials.gov