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Comprehensive Coronary Physiology in Patients With Angina With Nonobstructive Coronary Arteries - Czech Republic

NCT07103317 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1000

Last updated 2025-08-05

No results posted yet for this study

Summary

Coronary artery disease (CAD) is a leading cause of morbidity and mortality. While cardiologists have been focused on discrete, visible stenoses of coronary arteries, there is increasing awareness of the importance of microcirculation and vasospastic disorders in causing angina. The microvascular bed is composed of vessels smaller than 400 microns in diameter. Their network is significantly larger than that of the epicardial vessels and serves essential functions, including regulating myocardial blood flow and cellular metabolism.

Angina pectoris, a most frequent symptom of CAD or myocardial ischemia, was assumed to be caused by significant stenosis of the epicardial coronary artery. However, it was found that in over 50% of cases, there was no obstructive CAD, which is described as angina with no obstructive coronary arteries (ANOCA) or ischemia with no obstructive coronary arteries (INOCA), according to the clinical setting.

Conditions

  • ANOCA
  • ANOCA - Angina With Non-obstructive Coronary Arteries
  • MINOCA
  • Microvascular Dysfunction
  • Microvascular Angina
  • Vasospastic Angina
  • Acetylcholine

Sponsors & Collaborators

  • St. Anne's University Hospital Brno, Czech Republic

    collaborator OTHER

  • Nemocnice AGEL Trinec-Podlesi a.s.

    collaborator OTHER

  • Brno University Hospital

    collaborator OTHER

  • Institute for Clinical and Experimental Medicine

    collaborator OTHER_GOV

  • University Hospital, Motol

    lead OTHER

Principal Investigators

  • Petr Kala, M.D., Ph.D. · University Hospital Motol, Charles University

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-04-20
Primary Completion
2027-01-01
Completion
2030-01-01

Countries

  • Czechia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07103317 on ClinicalTrials.gov