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Neurobehavioral Signatures of Sign- and Goal-Tracking in Emerging Adults: Translation of a Preclinical Model

NCT07094061 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 294

Last updated 2026-04-27

No results posted yet for this study

Summary

This study seeks to understand individual differences in personality, brain function, and behavior.

Study hypothesis:

\- A stronger sign-tracking bias will be associated with a bottom-up processing style characterized by less adaptive attentional- and impulse-control as well as hyperactive reward processing, whereas a stronger goal-tracking bias will be associated with a top-down processing style characterized by strong attentional- and impulse-control as well as normative reward processing.

Conditions

  • Substance Use
  • Healthy

Interventions

BEHAVIORAL

Questionnaires and surveys

Participants will have multiple visits during this study and fill out various surveys at these visits.

BEHAVIORAL

Behavioral tasks and eye tracking

Participants will perform behavioral tasks while having eye-tracking hardware monitor participants eye movements. A video camera will be used to record eye movements during the behavioral tasks.

DEVICE

fMRI

Participants will have an MRI to scan participants brains and will wear skin conductance electrodes on the hand and fill out questionnaires. Scanning will take approximately 90 minutes. While lying in the scanner, participants will be asked to perform some tasks. The tasks will be presented to participants visually on a screen in the scanner and eye movements will also be tracked during some of these tasks. Participants will respond to stimuli with button presses that are recorded by computer.

Sponsors & Collaborators

Principal Investigators

  • Lora Cope, PhD · University of Michigan

Study Design

Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
22 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-10-03
Primary Completion
2027-10-31
Completion
2027-10-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07094061 on ClinicalTrials.gov