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Early Identification and Treatment of Rare Cardiomyopathy Cohorts

NCT06794710 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 300

Last updated 2025-01-27

No results posted yet for this study

Summary

This study aims to further develop an imaging-guided cohort of rare cardiomyopathies based on the existing database. The investigators will standardize the construction of a cohort that integrates a clinical data repository, serum biobank, myocardial tissue bank, and imaging database. In the current cohort, the investigators will systematically screen for biomarkers indicative of pathological changes in challenging cardiomyopathies. Multidimensional data will be integrated to establish and optimize a heart failure risk assessment model, which will then be validated in a prospective cohort. The effectiveness of the model in assessing different risk groups will be evaluated, with the goal of achieving precise prevention of heart failure from the source.

Conditions

  • Hypertrophic Cardiomyopathy (HCM)
  • Dilated Cardiomyopathy (DCM)
  • Metabolic Cardiomyopathy
  • Restrictive Cardiomyopathy

Interventions

DRUG

diuretics, ACEIs/ARBs, beta blockers, positive inotropic drugs, MRAs, SGLT2i, retinoids

Patients in this group will receive pharmacological treatment for heart failure.

BEHAVIORAL

Close follow-up

High risk patients receive close follow-up

BEHAVIORAL

early rehabilitation guidance

Early rehabilitation guidance such as cardiopulmonary exercise tests and cardiac rehabilitation therapy

Sponsors & Collaborators

  • RenJi Hospital

    lead OTHER

Principal Investigators

  • Meng Jiang, MD, PhD · RenJi Hospital, School of Medicine, Shanghai Jiantong University

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-02-01
Primary Completion
2027-05-30
Completion
2027-09-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06794710 on ClinicalTrials.gov