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Intermittent vs Continuous Enteral Nutrition in Glycaemic Control of Diabetic ICU Patients

NCT07054476 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 25

Last updated 2025-07-08

No results posted yet for this study

Summary

The goal of this clinical trial is to learn if intermittent or continuous enteral nutrition applications can improve glycemic control and affect certain metabolic parameters in adult critically ill patients with diabetes receiving clinical nutrition therapy. The main questions it aims to answer are:

Does intermittent enteral nutrition lead to better glycemic control compared to continuous enteral nutrition?

How do intermittent and continuous enteral nutrition applications affect metabolic parameters such as serum insulin levels, lipid profile, and inflammatory markers?

Researchers will compare intermittent and continuous enteral nutrition groups to see if one method is more effective in improving glycemic control and metabolic outcomes.

Participants will:

Receive either intermittent or continuous enteral nutrition as part of their clinical nutrition therapy

Have regular blood tests to monitor blood glucose, insulin, lipid profile, and inflammatory markers

Be monitored for glycemic variability and metabolic changes during their ICU stay

Conditions

Interventions

OTHER

Intermittent Enteral Nutrition

Intermittent Enteral Nutrition (IE): The intervention involves intermittent enteral nutrition using a diabetic-specific enteral formula, administered in 5 separate sessions daily with scheduled breaks between feedings. Each feeding session is followed by a break (1-2 hours). Energy needs are calculated based on the ESPEN guideline (25 kcal/kg/day). This protocol is designed to assess the effects of intermittent feeding in critically ill diabetic patients.

OTHER

Continuous Enteral Nutrition (CE)

Continuous Enteral Nutrition (CE): The intervention involves continuous enteral nutrition provided via a diabetic-specific enteral formula, administered 24 hours a day with 1-hour breaks between feeding sessions. The feeding rate starts at 40cc per hour and is gradually increased based on tolerance. Energy needs are calculated using the ESPEN guideline (25 kcal/kg/day).

Sponsors & Collaborators

  • Ankara Training and Research Hospital

    collaborator OTHER

  • Hacettepe University

    lead OTHER

Principal Investigators

  • Aslı Akyol Mutlu, Prof. · Hacettepe University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-12-02
Primary Completion
2024-06-16
Completion
2024-06-16

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07054476 on ClinicalTrials.gov