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Closed Loop Glucose Control in Intensive Care Unit

NCT01440842 · Status: COMPLETED · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 24

Last updated 2013-01-03

No results posted yet for this study

Summary

The purpose of this study is to assess the efficacy, safety and feasibility of a computer-based control algorithm to control glucose levels in adults in intensive care unit, in comparison to standard care.

Conditions

  • Stress Hyperglycaemia

Interventions

OTHER

Closed-loop insulin delivery

Intravenous infusion delivery of Actrapid insulin and dextrose, dose calculated by Model Predictive Control (MPC) algorithm, based on continuous glucose sensor readings.

OTHER

Standard IV insulin infusion sliding scale

Standard intravenous insulin infusion sliding scale as per intensive care unit protocol.

Sponsors & Collaborators

Principal Investigators

  • Roman Hovorka, BSc MSc PhD · University of Cambridge

  • Rowan Burnstein, MBBS FRCA PhD · Addenbrooke's Hospital, Cambridge, United Kingdom

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2012-05-31
Primary Completion
2012-10-31
Completion
2012-10-31

Countries

  • United Kingdom

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01440842 on ClinicalTrials.gov