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Comparative Evaluation of Hydrophilic and Hydrophobic Sealants in Partially Erupted First Molars

NCT07052526 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 150

Last updated 2025-07-09

No results posted yet for this study

Summary

This randomized controlled clinical trial aims to evaluate and compare the retention, caries prevention, microleakage, and fluoride release of three types of pit and fissure sealants-hydrophilic, nanofilled hydrophobic, and conventional hydrophobic-applied to partially erupted first permanent molars in children aged 5 to 7 years. The study uses a split-mouth design and includes both clinical and laboratory evaluations over an 18-month period. Outcomes will assess sealant effectiveness with and without the use of a bonding agent.

Conditions

  • Dental Caries

Interventions

OTHER

Prevention

Conventional Hydrophobic Sealant (Helioseal F - Control) will be used as a positive control; applied to partially erupted molars with and without bonding in a split-mouth design.

OTHER

Prevention of caries

Embrace WetBond sealant will be applied to partially erupted first permanent molars using a split-mouth design with and without bonding agent.

OTHER

Prevention therapy

DENU Seal applied using a split-mouth design to evaluate bonding and non-bonding application outcomes from retention and caries prevention

Sponsors & Collaborators

  • Mansoura University

    lead OTHER

Principal Investigators

  • Dr rabaa MAHMOUD ABOU Bakr, Professor · Mansoura University - Pediatric Dentistry Clinic

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
5 Years
Max Age
7 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2027-01-01
Completion
2027-04-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07052526 on ClinicalTrials.gov