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Effect of Moringa Royal Jelly on the Nutritional Status and Cognitive Level of Adolescent Girls

NCT07037498 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 372

Last updated 2025-08-08

No results posted yet for this study

Summary

The goal of this clinical trial is to learn whether a locally developed supplement called MRJ - a combination of Moringa oleifera (drumstick tree) extract and royal jelly - can improve the nutritional status and cognitive function of adolescent girls more effectively than standard iron and folic acid (IFA) tablets.

The main questions it aims to answer are:

Does MRJ supplementation lead to better improvements in nutrition (e.g., hemoglobin, body measurements)?

Does MRJ supplementation enhance cognitive function compared to IFA tablets?

Researchers will compare MRJ capsules to IFA tablets (the standard of care) among adolescent girls.

Participants will:

Take 2 MRJ capsules per week (intervention group) or 1 IFA tablet per week (control group) for 12 months

Receive nutrition education via short TikTok-based videos

Have their adherence monitored weekly by teachers and through WhatsApp photos

Measurements will be taken at the start, 6 months, and 12 months, including:

Height, weight, and mid-upper arm circumference (MUAC)

Hemoglobin levels via finger-prick blood test

Dietary intake using a 24-hour recall and food frequency questionnaire (FFQ)

Cognitive function assessed with the Culture Fair Intelligence Test (CFIT)

Participants are healthy junior and senior high school girls aged 10-18 years from Galesong Selatan, Takalar District, South Sulawesi, Indonesia.

Potential side effects (e.g., nausea or stomach discomfort) will be monitored according to school health protocols.

The findings may support the use of culturally appropriate, nutrient-rich interventions for improving adolescent girls' health and future well-being.

Conditions

  • Undernutrition
  • Anemia
  • Stunting
  • Cognitive Function 1, Social

Interventions

DIETARY_SUPPLEMENT

Moringa Oleifera

Participants receive MRJ capsules containing 490 mg of Moringa oleifera leaf extract and 10 mg of royal jelly, taken orally twice per week for 12 months. The capsules are plant-based, produced using locally sourced ingredients, and are part of a food-based supplementation strategy developed as an alternative to iron-folic acid tablets. The intervention is combined with standardized nutrition education via TikTok videos. Adherence is monitored weekly through teacher log sheets and WhatsApp documentation. and Participants receive iron-folic acid (IFA) tablets containing 60 mg of elemental iron and 400 µg of folic acid, taken orally once per week for 12 months in accordance with Indonesia's national supplementation guidelines for adolescent girls. This control intervention is combined with the same standardized nutrition education via TikTok videos. Compliance is tracked weekly through teacher-supervised control sheets and WhatsApp photo submissions.

Sponsors & Collaborators

  • Hasanuddin University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
12 Years
Max Age
19 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-02-10
Primary Completion
2025-06-10
Completion
2026-02-17

Countries

  • Indonesia

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07037498 on ClinicalTrials.gov