Multiple Micronutrient Supplementation for Maternal Anemia Prevention in Tanzania

Summary

This is an individually randomized controlled trial to assess the effect of multiple micronutrient supplements (MMS) containing 60 and 45 mg iron as compared to MMS containing 30 mg of iron (standard UNIMMAP formulation) on maternal moderate or severe anemia. This study will help inform countries like Tanzania that currently use IFA containing 60 mg of iron regarding the dose of iron to use in MMS.

Conditions

• Pregnancy Related

Interventions

DIETARY_SUPPLEMENT

Multiple Micronutrient Supplements with 30 mg of elemental iron

MMS with 30 mg iron is the active comparator group. The standard UNIMMAP MMS formulation includes 30 mg of iron which will be taken orally once daily from the time of randomization until delivery.

DIETARY_SUPPLEMENT

Multiple Micronutrient Supplements with 45 mg of elemental iron

MMS with 45 mg iron is an intervention group. MMS with 45 mg of iron plus standard UNIMMAP formulation for other 14 micronutrients will be taken orally once daily from the time of randomization until delivery.

DIETARY_SUPPLEMENT

Multiple Micronutrient Supplements with 60 mg of elemental iron

MMS with 60 mg iron is an intervention group. MMS with 60 mg of iron plus standard UNIMMAP formulation for other 14 micronutrients will be taken orally once daily from the time of randomization until delivery.

Sponsors & Collaborators

• Ifakara Health Institute

  collaborator OTHER

• Harvard School of Public Health (HSPH)

  collaborator OTHER

• Muhimbili University of Health and Allied Sciences

  collaborator OTHER

• Africa Academy for Public Health

  collaborator OTHER

• Columbia University

  collaborator OTHER

• George Washington University

  lead OTHER

Principal Investigators

• Blair Wylie, MD, MPH · Columbia University

• Honorati Masanja, PhD · Ifakara Health Institute

• Alfa Muhihi, MD, MPH · Africa Academy for Public Health

• Andrea Pembe, MD, MMed, PhD, FCOG · Muhimbili University of Health and Allied Sciences

• Emily R Smith, ScD, MPH · The Goerge Washington University

• Christopher R Sudfeld, ScD, ScM · Harvard University

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Sex

FEMALE

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-03-03

Primary Completion

2027-03-31

Completion

2027-06-30

Countries

• Tanzania

Study Locations