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Effect of Thiol-Disulfide Homeostasis and Ischemia-Modified Albumin Levels on IVF Results in Male Factor Infertility

NCT07033429 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 122

Last updated 2025-06-24

No results posted yet for this study

Summary

Thiol-disulfide Homeostasis (TDH) is essential for physiological functions in the human reproductive system, including antioxidant defense, detoxification, signal transduction, enzymatic regulation, apoptosis, and cellular communication. Ischemia-Modified Albumin (IMA) serves as an indicator of oxidative stress (OS) and is linked to ischemia-reperfusion injury. This study aimed to investigate changes in OS markers, particularly TDH and IMA levels, in couples with male infertility, and to examine the relationship between these markers and in vitro fertilization (IVF) success. Understanding how TDH and IMA levels influence IVF outcomes is crucial for advancing reproductive treatments for couples having diagnosis of infertility.

Conditions

  • The Serum Native Thiol (NT)
  • Total Thiol (TT)
  • Serum Disulfide/TT Ratio
  • NT/TT Ratio
  • Serum Ischemia-modified Albumin (IMA)

Sponsors & Collaborators

  • Duzce University

    lead OTHER

Principal Investigators

  • Müzeyyen Gülnur Özakşit, M.D., Professor · Ankara Bilkent City Hospital, IVF Unit

Eligibility

Min Age
23 Years
Max Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-04-01
Primary Completion
2023-10-31
Completion
2025-06-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07033429 on ClinicalTrials.gov