MedTrace Logo

Oxidative Stress-related Gene Expression in Cumulus Cells Among Low Responders

NCT03155438 · Status: UNKNOWN · Type: OBSERVATIONAL · Enrollment: 56

Last updated 2017-05-16

No results posted yet for this study

Summary

In Vitro Fertilization is considered one of effective treatment for infertile couple. However, some women do not have adequate response to controlled ovarian hyperstimulation, resulting in low response which defined as less than 5 retrieved oocytes. There are studies claiming that live birth rates in these patient lower than normal responder (10-15 retrieved oocytes). Among factors contributing low response, oxidative stress, resulting from increased pro-oxidant and/or reduced antioxidant, is considered to effect the functions of follicles and quality of oocytes. However, there are few studies demonstrating this relation. Objective of our study is to find the difference of oxidative stress-related gene expression in cumulus cell and oocyte competence biomarkers from follicular fluid between low responders and normal responder to controlled ovarian hyperstimulation.

Conditions

  • Low Responder

Interventions

DIAGNOSTIC_TEST

Oxidative stress-related gene expression (RNA expression)

Oxidative stress-related gene expression (RNA expression),Superoxide dismutase 1 (SOD1) , SOD2 , Glutathione peroxidase (GPX) and Inducible nitric oxide synthase (iNOS) , measured by Real time PCR technique.

DIAGNOSTIC_TEST

oocyte competence biomarkers

Oocyte competence biomarkers ,GDF9, BMP15, Amphiregulin and CoQ10 measured by ELISA

Sponsors & Collaborators

  • Chulalongkorn University

    lead OTHER

Principal Investigators

  • Porntip Sirayapiwat, MD · Chulalongkorn University

Eligibility

Min Age
25 Years
Max Age
49 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2017-06-01
Primary Completion
2018-03-30
Completion
2018-05-31

Countries

  • Thailand

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03155438 on ClinicalTrials.gov