MedTrace Logo

Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases

NCT07009990 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 100

Last updated 2025-06-08

No results posted yet for this study

Summary

Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs. Increasing evidence has been found that disorders of blood circulation in the smallest vessels of the heart and the brain share similar risk factors as well as mechanisms but evidence about the potential link between both remains scarce.

Therefore, this study wants to investigate whether in patients with acute first-time stroke, first-time generalized epileptic seizure or first-time transient global amnesia, impairment in microcirculation is found in the brain and in the heart within 72 hours after the onset of first symptoms. We also intend to examine differences in structural brain as well as cardiac health parameters and in blood biomarkers between patients with acute neurological diseases and healthy controls matched for age, sex and major cardiovascular risk factors like diabetes, smoking and high blood pressure. In addition, we will characterize the cohorts in terms of cognitive function and questionnaires on lifestyle and self-reported emotional functioning. We expect lower circulation in the smallest blood vessels in the brain and in the heart in patients with acute neurological diseases compared to healthy controls.

This pilot project is intended to demonstrate feasibility and initial results and thus serve as the basis for a larger clinical trial to improve long-term cerebral and cardiac health in patients with acute neurological diseases

Conditions

Sponsors & Collaborators

  • Department of Internal Medicine B, University Medicine Greifswald

    collaborator UNKNOWN

  • Institute for Diagnostic Radiology and Neuroradiology University Medicine Greifswald

    collaborator UNKNOWN

  • Department of Internal Medicine, First Clinic of Internal Medicine, University of Genoa, Italy

    collaborator UNKNOWN

  • University Medicine Greifswald

    lead OTHER

Principal Investigators

  • Agnes Flöel, Prof. Dr. · University Medicine Greifswald

  • Christian Templin, Prof. Dr. Dr. · University Medicine Greifswald

  • Claudia Schwarz, Dr. · University Medicine Greifswald

  • Davide Di Vece, Dr. · University Medicine Greifswald

Eligibility

Min Age
45 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-30
Primary Completion
2027-06-30
Completion
2027-06-30

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07009990 on ClinicalTrials.gov