MedTrace Logo

The Effect of Laparoscopic Sleeve Gastrectomy on Blood Phoenixin-14 Levels

NCT07004556 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 36

Last updated 2026-01-13

No results posted yet for this study

Summary

Obesity is a major global health concern with a rising prevalence and numerous associated comorbidities. For the treatment of severe obesity, bariatric surgery stands as the most effective procedure. Bariatric and metabolic surgical procedures are applied even in the absence of comorbidities, particularly in patients with Type-III obesity and above. Currently, the most commonly performed bariatric metabolic surgical procedures are Laparoscopic Sleeve Gastrectomy (LSG) and Roux-en-Y gastric bypass.

Animal studies have shown that phoenixin (PNX) in the paraventricular, arcuate, and solitary tract nuclei contributes to regulating food intake, and its intracerebral administration in rats increased food intake.

The aim of this study is to investigate whether PNX-14 levels change before and after LSG in patients undergoing the procedure for severe obesity, given the potential association of PNX-14 with obesity and insulin resistance through its influence on the appetite center in metabolism.

Conditions

  • Obesity, Morbid
  • Obesity and Overweight

Interventions

DIAGNOSTIC_TEST

Preoperative blood sampling for determining Phoenixin 14 levels

In addition to routine blood draws for pre-operative preparations, 5 ml of blood will be collected.

DIAGNOSTIC_TEST

Postoperative blood sampling for determining Phoenixin 14 levels

In addition to routine blood draws for postoperative controls, 5 ml of blood will be collected.

Sponsors & Collaborators

  • Kahramanmaras Sutcu Imam University

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2025-11-01
Completion
2025-11-01

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07004556 on ClinicalTrials.gov