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Intraoperative Nebulization of Lidocaine and Postoperative Pulmonary Complications

NCT07000760 · Status: COMPLETED · Phase: PHASE3 · Type: INTERVENTIONAL · Enrollment: 270

Last updated 2026-03-10

No results posted yet for this study

Summary

There is high incidence of postoperative pulmonary complications (PPCs) in patients undergoing major abdominal surgeries.PPCs significantly prolongs the hospital stay of patients, increases their economic burden, and raises the mortality rates within 30 days and 1 year after surgery. The inflammatory response during the perioperative period plays an important role in the occurrence and development of PPCs. The anti-inflammatory effect of lidocaine has a potential lung protection mechanism. The purpose of this study is to explore the effect of nebulization of lidocaine on the incidence of PPCs. The investigators hypothesized that intraoperative nebulization of lidocaine could reduce the incidence of PPCs.

Conditions

  • Postoperative Pulmonary Complications (PPCs)

Interventions

DRUG

Nebulization of lidocaine

After induction of general anesthesia and before the end of the surgery, 100mg of 2% lidocaine was nebulized and inhaled respectively, and the nebulization time was 15-20 minutes each time.

DRUG

Nebulization of normal saline

After anesthesia induction and before the end of the surgery, the same volume of normal saline (5ml of 0.9% NaCl) was nebulized, and the nebulization time was 15-20 minutes each time.

Sponsors & Collaborators

  • Jun Zhang

    lead OTHER

Principal Investigators

  • Jun Zhang Fudan University Shanghai Cancer Centre, Professor · Fudan University Shanghai Cancer Centre

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-06-06
Primary Completion
2026-01-23
Completion
2026-01-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07000760 on ClinicalTrials.gov