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Effects of Adrenergic Drugs on the Fluid Balance During Surgery

NCT01431612 · Status: COMPLETED · Phase: PHASE1/PHASE2 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2011-09-09

No results posted yet for this study

Summary

The aim this study was to examine to what degree the slow turnover of lactated Ringer's solution during anesthesia and surgery can be prevented by infusing esmolol (a ß1-receptor blocker) or phenylephrine in patients undergoing laparoscopic gynecological surgery performed under intravenous anesthesia.

Conditions

  • Ovarian Cyst

Interventions

DRUG

Esmolol administration

50 µg/kg/min of the ß1-receptor-blocker esmolol was infused intravenous over 3 hours

DRUG

Phenylephrine infusion

0.01 µg/kg/min of the alpha-1-adrenergic receptor agonist phenylephrine

DRUG

Lactated Ringer´s solution

Intravenous Infusion of 10 ml/h lactated Ringer's solution that contained no drug

Sponsors & Collaborators

  • Zhejiang University

    collaborator OTHER

  • Sodertalje Hospital

    lead OTHER

Principal Investigators

  • Robert G Hahn, MD, PhD · Södertälje Hospital, Södertälje, Sweden; Section for Anesthesia, Linköping University, Linköping, Sweden

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2008-11-30
Primary Completion
2010-10-31
Completion
2010-10-31

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT01431612 on ClinicalTrials.gov