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Diaphragmatic Physiology Similarity Index May Titrate HFNC Flow Setting: A Prospective Observational Study

NCT06996665 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 100

Last updated 2026-03-25

No results posted yet for this study

Summary

Study Objective This prospective observational study aims to investigate the role of the Diaphragmatic Physiology Similarity Index (DPSI) derived from speckle tracking ultrasound in titrating high-flow nasal cannula (HFNC) flow settings, and to evaluate its application in patients with acute respiratory failure.

Primary Research Questions

To characterize the features of the DPSI in healthy individuals and in patients with acute respiratory failure.

To assess the behavior of the DPSI under different HFNC flow settings in patients with acute respiratory failure.

Secondary Research Questions

Feasibility and inter-operator reproducibility of diaphragmatic speckle tracking.

Assessment of the Diaphragmatic Contraction Synchrony Index.

Evaluation of End-Diaphragmatic Residual Contraction (EDRC).

Additional fundamental parameters, including diaphragmatic displacement velocity and maximum displacement.

Conditions

Interventions

OTHER

High-flow adjustment sequence

Delivers heated, humidified blended oxygen via HFNC with real-time titration based on diaphragmatic speckle-tracking metrics (e.g., DPSI, contraction synchrony). Flow is adjusted in predefined increments to reach target diaphragmatic physiology while FiO₂ is titrated to maintain target SpO₂. Ultrasound feedback is used for bedside decisions; safety triggers allow clinical override.

Sponsors & Collaborators

  • Sir Run Run Shaw Hospital

    lead OTHER

Principal Investigators

  • Huiqing Ge · Sir Run Run Shaw Hospital

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-01
Primary Completion
2025-12-30
Completion
2026-12-02

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06996665 on ClinicalTrials.gov