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The Effect of the Menstrual Cycle on Immune Cell Activity and Recovery After Resistance Exercise

NCT06985420 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 40

Last updated 2025-05-22

No results posted yet for this study

Summary

The goal of this observational study is to learn how the menstrual cycle affects immune cell activation, recruitment, and recovery responses after resistance exercise in healthy, resistance-trained women aged 18-40. The main questions it aims to answer are:

Does the menstrual cycle influence neutrophil recruitment and adhesion after resistance exercise? Does the menstrual cycle affect markers of muscle damage and functional recovery? Researchers will compare three menstrual phases (early follicular, late follicular, and mid-luteal) to see if immune responses and recovery outcomes differ across these phases.

Participants will:

Complete resistance exercise protocols across three different menstrual cycle phases.

Provide blood samples to assess immune cell activation and muscle damage markers.

Track sleep, mood, and recovery with questionnaires and wear an accelerometer.

Conditions

  • Healthy Women
  • Menstruation
  • Resistance Exercise

Interventions

OTHER

Resistance exercise

Resistance Exercise Protocols: Participants will perform exercises, including belt squats, hex bar deadlifts, and plyometric drop jumps. The load and intensity will be standardized based on each participant's 1-repetition maximum (1RM) to ensure uniformity across trials.

OTHER

Menstrual Cycle Phases

Menstrual Cycle Phases: The key exposure variable is the phase of the menstrual cycle, with participants being assessed during the early follicular, late follicular, and mid-luteal phases.

Sponsors & Collaborators

  • University of Central Florida

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-08-16
Primary Completion
2025-05-31
Completion
2025-05-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06985420 on ClinicalTrials.gov