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Menstrual Cycle and Exercise-induced Muscle Damage

NCT07322874 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-02-03

No results posted yet for this study

Summary

The aim of the study is to investigate the effect of the different menstrual cycle phases on the recovery from exercise-induced muscle injury in eumenorrheic women. For this purpose, in a cross-over, randomized study, at least 10 healthy eumenorrheic women aged 18-35 years will participate. In a random order, the participants will perform 45 min downhill (-15% slope) running on a treadmill at 70% HRmax followed by a maximal time-trial (95% HRmax) to exhaustion: i) during the follicular phase and ii) during the luteal phase. Before the exercise protocol, as well as at 24 h, 48 h and 72 h following exercise, complete blood count, delayed onset of muscle soreness (DOMS), creatine kinase activity, countermovement jump, isometric, concentric and eccentric strength of knee extensors and knee flexors, will be assessed. In addition, lactic acid concentration will be assessed before and immediately following exercise, and DOMS will be assessed immediately after the end of exercise. Following a washout period of ≥28 days (depending on the length of the menstrual cycle), participants will repeat the exact same procedure for the remaining phase of the menstrual cycle.

Conditions

  • Menstrual Cycle Phase

Interventions

OTHER

Exercise during follicular phase

The participants will perform downhill running (-15% slope) on a treadmill at 70% of HRmax followed by running on a horizontal level (0% slope) at 95% HRmax until exhaustion, during the follicular phase

OTHER

Exercise during luteal phase

The participants will perform downhill running (-15% slope) on a treadmill at 70% of HRmax followed by running on a horizontal level (0% slope) at 95% HRmax until exhaustion, during the luteal phase

Sponsors & Collaborators

  • Chariklia K. Deli

    lead OTHER

Principal Investigators

  • Chariklia K Deli, Associate Professor, MSc, PhD · University of Thessaly

Study Design

Allocation
RANDOMIZED
Purpose
SCREENING
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-03-01
Primary Completion
2025-12-30
Completion
2025-12-30

Countries

  • Greece

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07322874 on ClinicalTrials.gov