Comparative Effectiveness of Tirzepatide vs Semaglutide in Participants With Type 2 Diabetes and Heart Failure With Preserved Ejection Fraction
NCT06980623 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 26000
Last updated 2026-05-15
Summary
This cohort study aims to assess the comparative effectiveness of tirzepatide versus semaglutide with respect to cardiovascular events in patients with type 2 diabetes and heart failure with preserved ejection fraction.
Conditions
Interventions
- DRUG
-
Exposure group
- DRUG
-
Referent group
Sponsors & Collaborators
-
Brigham and Women's Hospital
lead OTHER
Eligibility
- Min Age
- 18 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2025-01-01
- Primary Completion
- 2025-11-30
- Completion
- 2026-10-01
- FDA Drug
- Yes
Countries
- United States
Study Locations
More Related Trials
-
Prediction of the SURPASS-CVOT Cardiovascular Outcome Trial in Healthcare Claims Data
NCT07088718 ·Status: COMPLETED
-
A Study of Tirzepatide (LY3298176) in Participants With Heart Failure With Preserved Ejection Fraction (HFpEF) and Obesity: The SUMMIT Trial
NCT04847557 ·Status: COMPLETED ·Phase: PHASE3
-
Tirzepatide: Reversal of Lipotoxicity and Adipose Tissue Dysfunction in Humans With Overweight/Obesity
NCT05912621 ·Status: RECRUITING ·Phase: PHASE2
-
Research Study to Look at How Well Semaglutide Works in People Living With Heart Failure, Obesity and Type 2 Diabetes
NCT04916470 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Tirzepatide (LY3298176) Compared With Placebo in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06914895 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Tirzepatide for the Treatment of Concurrent Type 1 Diabetes and Overweight or Obesity
NCT06180616 ·Status: NOT_YET_RECRUITING ·Phase: PHASE2
-
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have Obesity
NCT06662383 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
Effect of Weight Loss on Physical and Cardiac Performance in People With Obesity and Heart Failure
NCT06423599 ·Status: RECRUITING ·Phase: PHASE2/PHASE3
-
Comparative Study of Tirzepatide Versus Dulaglutide (SURPASS CVOT) or Semaglutide on Major Cardiovascular Events in Participants With Type 2 Diabetes
NCT06779929 ·Status: COMPLETED
-
A Study of Tirzepatide (LY3298176) in Participants With Type 2 Diabetes Who Have Obesity or Are Overweight
NCT04657003 ·Status: COMPLETED ·Phase: PHASE3
-
Semaglutide vs Dulaglutide on Epicardial Adipose Tissue
NCT04200625 ·Status: COMPLETED
-
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight for the Maintenance of Weight Loss
NCT04660643 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of Tirzepatide (LY3298176) Compared With Standard of Care in Adult Participants With Obesity and Without Diabetes (SURMOUNT-REAL UK)
NCT07247084 ·Status: RECRUITING ·Phase: PHASE4
-
A Long-Term Study of Tirzepatide (LY3298176) in Adults With Type 1 Diabetes and Obesity or Overweight
NCT06962280 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Tirzepatide (LY3298176) Plus Mibavademab Compared With Tirzepatide Alone in Adult Participants With Obesity
NCT06373146 ·Status: COMPLETED ·Phase: PHASE2
-
The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease
NCT06606821 ·Status: RECRUITING ·Phase: PHASE4
-
Bariatric Surgery vs. Semaglutide vs. Tirzepatide
NCT06803888 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
A Study of Tirzepatide (LY3298176) Compared to Dulaglutide in Participants With Type 2 Diabetes
NCT03861052 ·Status: COMPLETED ·Phase: PHASE3
-
A Study to Investigate Weight Management With LY3841136 and Tirzepatide (LY3298176), Alone or in Combination, in Adult Participants With Obesity or Overweight With Type 2 Diabetes
NCT06603571 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE2
-
A Study of Tirzepatide (LY3298176) In Participants After A Lifestyle Weight Loss Program
NCT04657016 ·Status: COMPLETED ·Phase: PHASE3
-
Effect of Oral Semaglutide on Epicardial and Pericoronary Adipose Tissues in Type 2 Diabetes After Myocardial Infarction
NCT06557811 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
A Study of Tirzepatide (LY3298176) on the Reduction on Morbidity and Mortality in Adults With Obesity
NCT05556512 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE3
-
A Study of Tirzepatide (LY3298176) in Participants With Obesity or Overweight
NCT04184622 ·Status: COMPLETED ·Phase: PHASE3
-
A Study of LY3298176 (Tirzepatide) For the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities
NCT06047548 ·Status: COMPLETED ·Phase: PHASE3
-
Cardiac and Metabolic Effects of Semaglutide in Heart Failure With Preserved Ejection Fraction
NCT05371496 ·Status: ENROLLING_BY_INVITATION ·Phase: PHASE2