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Acute Oral Ketone Monoester Supplementation and Resting-state Brain Connectivity

NCT06962501 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-05-18

No results posted yet for this study

Summary

The primary objectives of this pilot study are to test if a single dose of an oral ketone monoester supplement will increase blood flow and connectivity in the brain in adults with subjective cognitive decline (SCD) or mild cognitive impairment (MCI).

The main questions it aims to answer are:

Does a single dose of an oral ketone supplement increase global cerebral blood flow (CBF)?

Does a single dose of an oral ketone supplement improve resting-state functional connectivity in the Default Mode Network (DMN)?

Does the increase in CBF positively correlate with improved functional connectivity in the DMN?

Participants will:

* Attend one 2-hour session, which includes:
* Neurocognitive assessment
* MRI Scans (two, each 15 Minutes)
* Capillary blood ketone level measurements
* Hemodynamic assessment (blood pressure, heart rate)

Conditions

Interventions

DIETARY_SUPPLEMENT

Oral ketone monoester (KME)

The oral ketone monoester supplement should increase the global CBF and improve resting-state connectivity in the DMN in adults with SCD or MCI. The participants will take one dose of the supplement followed by measurement, to figure out if there are any noticeable changes.

Sponsors & Collaborators

  • McMaster University

    collaborator OTHER

  • University Department of Geriatric Medicine FELIX PLATTER

    lead OTHER

Principal Investigators

  • Sabine Krumm, PD, PhD · University Department of Geriatric Medicine FELIX PLATTER

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-04-12
Primary Completion
2026-04-18
Completion
2026-04-18

Countries

  • Switzerland

Study Locations

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Diseases
Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06962501 on ClinicalTrials.gov