AI-Enhanced Optimization of Acute Levodopa Challenge Test

Summary

A quantitative evaluation method was developed for Parkinson's disease and other atypical parkinonism by integrating an innovative motor paradigm with perception technologies and artificial intelligence. Combined with traditional motor paradigms and the acute levodopa challenge test, this study aims to identify diagnostic cut-off values for PD and other atypical parkinonism, explore digital biomarkers for early and differential diagnosis, and establish a corresponding diagnostic model.

Conditions

• Vascular Parkinsonism
• Drug-induced Parkinsonism
• Corticobasal Degeneration (CBD)
• Parkinson Disease (PD)
• Dementia With Lewy Body Disease
• Progressive Supranuclear Palsy(PSP)
• Multiple System Atrophy (MSA)

Interventions

OTHER

video recording

The patient's motor symptoms were recorded via video for assessment purposes.

Sponsors & Collaborators

• Ruijin Hospital

  collaborator OTHER

• Nanjing Medical University

  collaborator OTHER

• Second Affiliated Hospital of Soochow University

  collaborator OTHER

• Beijing Hospital

  collaborator OTHER_GOV

• Fujian Medical University Union Hospital

  collaborator OTHER

• Guangdong Provincial People's Hospital

  collaborator OTHER

• West China Hospital

  collaborator OTHER

• The First Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• China-Japan Union Hospital, Jilin University

  collaborator OTHER

• Renmin Hospital of Wuhan University

  collaborator OTHER

• First Affiliated Hospital of Chongqing Medical University

  collaborator OTHER

• Second Affiliated Hospital of Nanchang University

  collaborator OTHER

• Xijing Hospital

  collaborator OTHER

• The Affiliated Hospital of Qingdao University

  collaborator OTHER

• The Second Affiliated Hospital of Xinjiang Medical University

  collaborator UNKNOWN

• Shenzhen People's Hospital

  collaborator OTHER

• Tianjin Medical University General Hospital

  collaborator OTHER

• Qilu Hospital of Shandong University

  collaborator OTHER

• The First People's Hospital of Yunnan

  collaborator OTHER

• The First Hospital of Jilin University

  collaborator OTHER

• Tianjin Huanhu Hospital

  collaborator OTHER

• The First Affiliated Hospital of Anhui Medical University

  collaborator OTHER

• Wannan Medical College Yijishan Hospital

  collaborator OTHER

• The Affiliated Hospital of Xuzhou Medical University

  collaborator OTHER

• Beijing Tiantan Hospital

  lead OTHER

Eligibility

Min Age

50 Years

Max Age

75 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2024-05-28

Primary Completion

2026-12-31

Completion

2026-12-31

Countries

• China

Study Locations