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Using Xe MRI to Guide Radiation Therapy for Lung Cancer

NCT06925295 · Status: RECRUITING · Phase: PHASE2 · Type: INTERVENTIONAL · Enrollment: 15

Last updated 2026-01-02

No results posted yet for this study

Summary

The purpose of this research study is to explore using MRI scans with xenon to better image lung function, how lung function changes after radiation therapy, and to guide radiation therapy away from parts of the lung that have good function. This project is foundational to performing additional studies to establish if novel MRI imaging can serve as a guidance tool for lung cancer radiation treatment.

Conditions

  • Imaging Techniques

Interventions

DRUG

Xenon MRI

MRI with Xenon used for contrast

DIAGNOSTIC_TEST

Pulmonary Function Testing

Pulmonary function testing will include spirometry, lung volumes, DLCO and oscillometry

OTHER

Quality of Life Questionnaire

European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30+QLQ-LC29)

OTHER

Medical Research Council Dyspnea score

modified Medical Research Council Dyspnea score (mMRC Dyspnea)

OTHER

St. George's Respiratory Questionnaire

St. George's Respiratory Questionnaire (SGRQ)

DIAGNOSTIC_TEST

Blood Biomarkers

blood biomarkers of inflammation and injury (e.g. Angiopoetin-2, Interleukin-6, myofibroblast activity, BPD4)

Sponsors & Collaborators

  • Sean Fain

    lead OTHER

Principal Investigators

  • Sean Fain, PhD · University of Iowa

Study Design

Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-08-30
Primary Completion
2027-01-31
Completion
2027-01-31
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06925295 on ClinicalTrials.gov