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DECAMP-2: Screening of Patients With Early Stage Lung Cancer or at High Risk for Developing Lung Cancer

NCT02504697 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 665

Last updated 2026-04-01

No results posted yet for this study

Summary

The goal of this project is to improve lung cancer screening in high-risk individuals by identifying biomarkers of preclinical disease and disease risk that are measured in minimally invasive and non-invasive biospecimens. Existing biomarkers for lung cancer diagnosis as well as new biomarkers discovered specifically in this clinical setting will be examined. Biomarkers that identify individuals at highest risk for being diagnosed with lung cancer prior to the appearance of concerning symptoms could increase the utility of lung cancer surveillance and the efficiency of lung cancer chemoprevention clinical trials. Achieving these goals would improve the detection and treatment of early stage and incipient lung cancer, while restricting the risk of these procedures to those individuals who currently exhibit the early molecular warning signs of impending disease.

Conditions

  • Pulmonary Disease

Interventions

OTHER

Biosamples from airway and blood

Identify biomarkers in biosamples from airway and blood for the preclinical detection of lung cancer.

Sponsors & Collaborators

  • American College of Radiology Imaging Network

    collaborator NETWORK

  • Boston University

    lead OTHER

Principal Investigators

  • Ehab Billatos, MD · Boston University

  • Denise Aberle, MD · University of California, Los Angeles

Eligibility

Min Age
50 Years
Max Age
79 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2011-09-30
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02504697 on ClinicalTrials.gov