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Improving Pulmonary Function Following Radiation Therapy

NCT02843568 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 122

Last updated 2024-10-10

Study results available
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Summary

The purpose of this study is to develop radiation plans that will help preserve lung function in healthy tissue surrounding the tumor. We believe that 4DCT scans can be useful in designing radiation treatment plans that help us avoid healthy normal functioning lung tissue close to lung tumors. Currently 4DCT scans are used to help us determine exactly where the tumor is and how it moves when you breathe. In this study we will also use the 4DCT scans to try to identify high functioning normal lung tissue.

Conditions

Interventions

OTHER

Laboratory Biomarker Analysis

Correlative studies

RADIATION

Standard fractionation

60-66y Gy delivered in 1.8-2.0 Gy fractions over 30-36 treatments

RADIATION

Stereotactic Body Radiation Therapy (SBRT)

40-60 Gy delivered in 5-20 Gy fractions over 3-8 treatments

PROCEDURE

Four Dimensional Computed Tomographic Imaging (4DCT)

Subjects undergo a total of 7 research-ordered four dimensional computed tomographic imaging (4DCT) scans: 1 at simulation, and 2 scans at each of the 3 post-radiation therapy time points (3, 6, and 12 months). 4DCT determines lung tissue elasticity and for standard of care radiation treatment planning.

Sponsors & Collaborators

  • National Cancer Institute (NCI)

    collaborator NIH

  • University of Wisconsin, Madison

    lead OTHER

Principal Investigators

  • Carri K Glide-Hurst, PhD, DABR, FAAPM · University of Wisconsin, Madison

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2016-08-17
Primary Completion
2022-10-28
Completion
2023-08-16
FDA Device
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT02843568 on ClinicalTrials.gov