Optimization of Chrononutrition to Reduce the Risk of Disease in Shift Workers

Summary

In this randomized controlled trial, the investigators will assess the health impacts of optimizing the timing of dietary consumption in nurses and nursing assistants who work night shifts, have a habitual eating window of 14 hours or more, and elevated weight. Participants will be randomized to one of three groups: (1) dietary monitoring, (2) dietary monitoring plus 10-hour daytime time-restricted eating (TRE), or (3) TRE with a low-glycemic snack during night shifts. The study includes a 2-week screening/baseline health assessment, with follow-up health assessments at 3-, 6- (primary outcome), and 12 months.

Conditions

• Night Shift Work
• Time Restricted Eating
• Overweight
• Obesity

Interventions

BEHAVIORAL

Dietary Monitoring

Participants in the group will receive standard advice for a healthy lifestyle, log all food and beverage intake on the myCircadianClock app, and continue their habitual eating patterns.

BEHAVIORAL

Time-Restricted Eating (TRE)

Participants in the group will receive standard advice for a healthy lifestyle, log all food and beverage intake on the myCircadianClock app, and adhere to a personalized consistent 10-hour time-restricted eating window.

BEHAVIORAL

Time-Restricted Eating with a Low-Glycemic Snack (TRE-LGS)

Participants in the group will receive standard advice for a healthy lifestyle, log all food and beverage intake on the myCircadianClock app, and adhere to a personalized consistent 10-hour time-restricted eating window. On nights that participants work night shifts, they will consume a low-glycemic snack provided by the research team.

Sponsors & Collaborators

• National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)

  collaborator NIH

• University of San Diego

  collaborator OTHER

• Salk Institute for Biological Studies

  lead OTHER

Principal Investigators

• Emily Manoogian, Ph.D. · Salk Institute for Biological Studies

Study Design

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

70 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2025-06-02

Primary Completion

2028-08-31

Completion

2029-03-03

Countries

• United States

Study Locations