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Physical, Psychological and Socioeconomic Effects of Childhood Onset Diabetes in Sweden

NCT06883318 · Status: ACTIVE_NOT_RECRUITING · Type: OBSERVATIONAL · Enrollment: 115000

Last updated 2025-03-24

No results posted yet for this study

Summary

The researchers study time trends of childhood-onset type 1 diabetes and its most serious complication, end-stage renal disease. They further analyse physical, psychological and socio-economic long-term effects on patients and families to identify potentially preventive factors in a population perspective. The researchers investigate the economic burden of disease and study and improve statistical methods for case-control data. The projects use a longitudinal nationwide database involving about 23 000 childhood-onset diabetes cases with maximum follow-up of 48 years and for each case 4 matched controls. The Swedish Childhood Diabetes Register is linked to a number of official, Swedish registers: the Renal register, the Cause of Death register, the National Patient register, the Prescribed Drugs register, the Cancer register and the Integrated Database for Labour Market Research. The researchers use GAM modelling for time trend analyses, standard case-control/cohort analyses, Cox regression for life table analyses, linear fixed effect probability for career development and propensity score models for confounding. The project group is multidisciplinary and involves experts in paediatrics, nephrology, epidemiology, health economics and statistics. This unique database and team continues to yield population-based new knowledge on the consequences of this increasingly common chronic childhood-onset disease.

Conditions

  • Type 1 Diabetes Mellitus (T1DM)
  • End-Stage Renal Disease

Sponsors & Collaborators

  • Uppsala University

    collaborator OTHER

  • Lund University

    collaborator OTHER

  • The Swedish Research Council

    collaborator OTHER_GOV

  • Umeå University

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2019-05-08
Primary Completion
2029-12-31
Completion
2029-12-31

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT06883318 on ClinicalTrials.gov