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LIVEBETTER: A Trial Comparing Medications in Older Adults With Stable Angina and Multiple Chronic Conditions

NCT05786417 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 741

Last updated 2026-04-07

No results posted yet for this study

Summary

To establish the effectiveness and tolerability of standard of care anti-anginal treatment (beta-blocker and calcium channel blocker medications) in older adults with symptomatic Stable Ischemic Heart Disease (SIHD) and multiple chronic conditions (MCC).

Conditions

  • Angina
  • Stable Ischemic Heart Disease

Interventions

OTHER

Clinician Discretion

Clinician discretion as to which BB or CCB will be used if the participant has a heart rate and blood pressure within normal limits.

DRUG

Beta blocker

Selection of the specific BB and initial starting dose will be determined by the treating clinician.

DRUG

Calcium channel blocker

Selection of the specific CCB and initial starting dose will be determined by the treating clinician.

Sponsors & Collaborators

  • Yale University

    lead OTHER

Principal Investigators

  • Michael Nanna, MD · Yale University

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2023-05-10
Primary Completion
2027-05-30
Completion
2027-05-30
FDA Drug
Yes

Countries

  • United States

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT05786417 on ClinicalTrials.gov